반응 #2151238

반응 방정식

dimethylformamide

4-bromo-2-fluoro-1-nitro-benzene

D9

1-(Tetrahydro-2H-pyran-4-yl)-4-piperidinamine

diisopropylethylamine

→

N-(5-bromo-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine

용매

water

반응 조건

후처리

1. 1
   추출the reaction extracted with 2×75 mL of dichloromethane
2. 2
   건조dried with sodium sulfate
3. 3
   기타evaporated

실험 절차

400 mg (0.0018 mol, 1 eq) of 4-bromo-2-fluoro-1-nitro-benzene, 330 mg (0.0018 mol, 1 eq) of D9, 350 mg (0.0027 mol, 1.5 eq) of diisopropylethylamine, and 5 mL of dimethylformamide were combined, heated to 200° C. and held for 1 min in a microwave reactor. 80 mL of water was then added and the reaction extracted with 2×75 mL of dichloromethane. The dichloromethane layers were combined, dried with sodium sulfate, and evaporated to yield N-(5-bromo-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine which was used without further purification in the next step. MS (ESI): 385 [M+H]+.

출처