반응 #2150

반응 방정식

[1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide

[1-(3-Phenylxanthin-1-yl)methyl]dimethylphosphine Oxide

chloromethylcyclopropane

potassium carbonate

→

[1-(7-Cyclopropylmethyl-3-phenylxanthin-1-yl)methyl]dimethylphosphine Oxide

반응 조건

후처리

1. 1
   여과The solution was filtered
2. 2
   농축concentrated
3. 3
   기타the residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1)

실험 절차

3.9 g (0.0123 mol) of [1-(3-phenylxanthin-1-yl)methyl]dimethylphosphine oxide (Example 70) were stirred at 70° C. for 6 hours with 1.33 g (0.0147 mol) of chloromethylcyclopropane and 2 g of potassium carbonate. The solution was filtered and concentrated, and the residue which remained was chromatographed on silica gel (eluent: ethyl acetate/methanol 10:1).

출처