반응 #2148688

반응 방정식

(2-amino-3-fluoro-5-methylphenyl)[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]amine

tetrahydrofuran

tetrahydrofuran

→

title compound

4-fluoro-6-methyl-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

반응 조건

후처리

1. 1
   온도was heated to reflux
2. 2
   온도the mixture heated
3. 3
   온도at reflux for a further 1½ hours
4. 4
   여과The reaction mixture was filtered
5. 5
   세척washed with tetrahydrofuran (10 ml)
6. 6
   기타the solid was dried at 40-45° C. under high vacuum

실험 절차

A mixture of (2-amino-3-fluoro-5-methylphenyl)[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]amine (0.5 g), N,N′-carbonyldiimidazole (0.66 g) and tetrahydrofuran (7 ml) was heated to reflux. After 30 minutes, tetrahydrofuran (3 ml) was added, and the mixture heated at reflux for a further 1½ hours. The reaction mixture was filtered and washed with tetrahydrofuran (10 ml), then the solid was dried at 40-45° C. under high vacuum to give the title compound (0.323 g).

출처