반응 #214844

반응 방정식

N-benzyloxycarbonyl-L-aspartic acid

L-phenylalanine methyl ester

→

N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester

L-phenylalanine methyl ester

수율 95.5%

용매

반응 조건

후처리

1. 1
   기타The precipitate was collected
2. 2
   세척washed with water
3. 3
   기타dried

실험 절차

A 267.2 mg (1 m mol) of N-benzyloxycarbonyl-L-aspartic acid and 537.6 mg (3 m mol) of L-phenylalanine methyl ester were dissolved in 5 ml of McIlvain's buffer solution (pH:7.0). The resulting solution was admixed with 100 mg of Thermoase and 100 mg of potato inhibitor and shaken at 38° C. for 20 hours. The precipitate was collected and washed with water and dried to obtain 580 mg of a crude crystalline addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester and L-phenylalanine methyl ester (1:1) (melting point: 123° to 125° C.; Yield: 95.5% based on N-benzyloxycarbonyl-L-aspartic acid).

출처