반응 #214770

반응 방정식

1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile

p-aminophenol

→

1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile

용매

xylene

반응 조건

후처리

1. 1
   온도is refluxed for 2 hours
2. 2
   여과filtered hot
3. 3
   온도The filtrate is chilled
4. 4
   기타the crystals formed
5. 5
   기타collected
6. 6
   기타recrystallized from methanol

실험 절차

The mixture of 5.7 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 3,6 g of p-aminophenol and 300 ml of xylene is refluxed for 2 hours and filtered hot. The filtrate is chilled, the crystals formed collected and recrystallized from methanol, to yield the 1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile melting at 182°-184°.

출처