반응 #214769

반응 방정식

1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile

aniline

→

1-methyl-β-oxo-α-phenylcarbamoyl-2-pyrrolpropionitrile

용매

xylene

반응 조건

후처리

1. 1
   온도is refluxed for 41/2 hours
2. 2
   여과the solution is filtered
3. 3
   기타evaporated
4. 4
   기타the residue recrystallized from methanol

실험 절차

The mixture of 1.1 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 1.1 g of aniline and 60 ml of xylene, is refluxed for 41/2 hours. After standing and cooling to room temperature overnight, the solution is filtered, evaporated and the residue recrystallized from methanol, to yield the 1-methyl-β-oxo-α-phenylcarbamoyl-2-pyrrolpropionitrile melting at 173°-174°; it is identical with that obtained according to Example 1.

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