반응 #2146838

반응 방정식

5-nitroisophtalic acid monoethyl ester

oxalyl chloride

DMF

→

title compound

3-Chlorocarbonyl-5-nitro-benzoic acid ethyl ester

용매

DCM

DCM

반응 조건

후처리

1. 1
   농축concentrated in vacuum
2. 2
   기타The residue was triturated with toluene
3. 3
   농축again concentrated in vacuum

실험 절차

To a solution of 5-nitroisophtalic acid monoethyl ester (80 g) in DCM (700 ml) at 25° C. was added 2M oxalyl chloride solution in DCM (63 ml), and DMF (5 ml). The reaction was stirred for 2 h and then concentrated in vacuum. The residue was triturated with toluene and again concentrated in vacuum leaving the title compound (60 g). Rt=1.40 min for derivatised methylester (method D).

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