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6,7-diacetamino1,4-benzodioxane-5-carboxylic acid

6,7-diamino-1,4-benzodioxane-5-carboxylic acid

1-piperidinopropylamine

→

N-(1-piperidinopropyl)-6,7-diacetamino-1,4-benzodioxane-5-carboxamide

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실험 절차

In the same manner as described in Example 53, the 6,7-diacetamino1,4-benzodioxane-5-carboxylic acid (prepared by acetylation of the 6,7-diamino-1,4-benzodioxane-5-carboxylic acid) was condensed with the 1-piperidinopropylamine in the presence of the isobutyl chloroformiate. The N-(1-piperidinopropyl)-6,7-diacetamino-1,4-benzodioxane-5-carboxamide was obtained (M.P.: above 260° C. with decomposition). The structure was confirmed by nuclear magnetic resonance analysis.

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