반응 #2146063

반응 방정식

N-(3-trifluoromethylphenyl)-N-benzylamine

isopropyl phosphonic dichloride

→

1-isopropyl-2-(3-trifluoromethylphenyl)-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide

반응 조건

후처리

1. 1
   기타The crude product produced as
2. 2
   기타a result of the chromatographic separation
3. 3
   기타was crystallized from methylcyclohexane
4. 4
   기타to yield a tan precipitate
5. 5
   기타The tan precipitate was recrystallized from toluene and petroleum ether

실험 절차

The procedure of Example 1 was employed utilizing N-(3-trifluoromethylphenyl)-N-benzylamine and isopropyl phosphonic dichloride. The crude product produced as a result of the chromatographic separation was crystallized from methylcyclohexane to yield a tan precipitate. The tan precipitate was recrystallized from toluene and petroleum ether to yield 1-isopropyl-2-(3-trifluoromethylphenyl)-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide as beige plates. A second crop was obtained to give a total yield of 5.9 g, (29% yield) of 1-isopropyl-2-(3-trifluoromethylphenyl)-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide having a melting point of 117°-119° C. and the following analysis:

출처