반응 #214478

반응 방정식

L-Cysteine

2-methyl-2-(methylthio)propanoyl chloride

hydrochloric acid

→

titled compound

수율 89.8%

N-[2-Methyl-2-(methylthio)propanoyl]-L-cysteine

수율 89.8%

용매

potassium carbonate

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe mixture is stirred overnight at room temperature
3. 3
   기타the obtained crystals are separated by filtration
4. 4
   기타dried

실험 절차

L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.

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