반응 #2144484

ord-e7b9eda98fa4408eba748a5bef2c4750

반응 방정식

CCNCCO
2-ethylamino-ethanol
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride
→
CCN(CCO)CCCC[C@H]1CC[C@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
trans-N-(4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide

반응물

CCNCCO
2-ethylamino-ethanol
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with 2-ethylamino-ethanol to give trans-N-(4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 465 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07335687B2uspto-grants-2008_02