반응 #214320

반응 방정식

1-Ethylpropylamine

2-acetamido-5-chlorosulfonyl-1,3,4-thiadiazole

hydrochloric acid

→

2-acetamido-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole

용매

water

반응 조건

후처리

1. 1
   기타fitted with a mechanical stirrer
2. 2
   workup.ADDITIONis added slowly
3. 3
   기타the reaction temperature between 0° C. and 20° C
4. 4
   workup.ADDITIONAt the conclusion of the addition
5. 5
   여과Solids are filtered out
6. 6
   세척water washed
7. 7
   기타dried

실험 절차

1-Ethylpropylamine (0.1 mole) and water (50 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer. The solution is cooled to 20° C. and stirred while 2-acetamido-5-chlorosulfonyl-1,3,4-thiadiazole (0.1 mole) is added slowly while holding the reaction temperature between 0° C. and 20° C. At the conclusion of the addition, stirring is continued for a period of about 2 hours at room temperature. The reaction mixture is then neutralized with 6 N hydrochloric acid. Solids are filtered out, water washed and dried to yield the desired product 2-acetamido-5-[N-(1-ethylpropyl)aminosulfonyl]-1,3,4-thiadiazole.

출처