반응 #214315

반응 방정식

2-Bromo-1,1-dimethoxyethane

1,3-butanediol

Toluene sulfonic acid

→

2-bromomethyl-4-methyl-1,3-dioxane

반응 조건

후처리

1. 1
   기타fitted with a mechanical stirrer
2. 2
   온도thermometer, Dean Stark trap and reflux condenser
3. 3
   온도the reaction mixture is heated
4. 4
   기타alcohol removed
5. 5
   workup.ADDITIONtreated with sodium carbonate (5 grams)
6. 6
   여과filtered
7. 7
   기타a rotary evaporator

실험 절차

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.

출처