반응 #214122

반응 방정식

4-(hexadecylamino)benzoic acid

lactic acid

toluenesulfonic acid

→

1-carboxyethyl 4-(hexadecylamino)benzoate

용매

toluene

반응 조건

후처리

1. 1
   workup.ADDITIONA flask containing 10.0 g
2. 2
   workup.ADDITIONcharged
3. 3
   온도The solution is refluxed for 24 hours, during which time the Soxhlet extractor
4. 4
   workup.ADDITIONis charged twice more with fresh sieves
5. 5
   여과The hot solution is filtered
6. 6
   workup.WAITleft
7. 7
   온도to cool, whereupon the product

실험 절차

A flask containing 10.0 g. (27.7 m moles) 4-(hexadecylamino)benzoic acid, 3.3 g. (36 m moles) lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene is equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours, during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon the product separates as off-white crystals.

출처