반응 #2139917

반응 방정식

4-methyl-3-thiosemicarbazide

acetone

chloroacetone

→

3,4-Dimethyl-2(3H)-thiazolone-(1-methylethyliden) hydrazone

반응 조건

후처리

1. 1
   온도at reflux for 2 hours
2. 2
   온도The reaction mixture was heated
3. 3
   온도at reflux for 7 hours
4. 4
   농축concentrated
5. 5
   기타The resulting crude product was recrystallized from acetone

실험 절차

21 g (200 mmol) of 4-methyl-3-thiosemicarbazide in 1000 mL of acetone was heated at reflux for 2 hours. To the solution was then added dropwise 20.4 g (220 mmol) of chloroacetone. The reaction mixture was heated at reflux for 7 hours and concentrated. The resulting crude product was recrystallized from acetone. This gave 23 g of an orange powder (63% of the theoretical).

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