반응 #213964

반응 방정식

sodium hydroxide

3-nitrophenol

2,3-dichloropyrazine

→

2-chloro-3-(3-nitrophenoxy)pyrazine

수율 46.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도the resulting solution refluxed for 162 hours
2. 2
   온도The reaction mixture was cooled
3. 3
   농축concentrated
4. 4
   workup.ADDITIONUpon pouring the
5. 5
   농축concentrate into approximately 300 ml of water
6. 6
   기타an off-white solid precipitated which
7. 7
   여과was collected by filtration
8. 8
   기타Recrystallization from absolute ethanol

실험 절차

In a 250-ml single-necked, round-bottomed flask containing a solution of 3.0 g (75 mmol) of sodium hydroxide in 100 ml of absolute ethanol was added 9.28 g (67 mmol) of 3-nitrophenol at which point the solution turned dark red. To the dark red solution, 10.0 g (66 mmol) of 2,3-dichloropyrazine was added and the resulting solution refluxed for 162 hours. The reaction mixture was cooled and concentrated. Upon pouring the concentrate into approximately 300 ml of water, an off-white solid precipitated which was collected by filtration. Recrystallization from absolute ethanol gave the product, 2-chloro-3-(3-nitrophenoxy)pyrazine, (46% yield) as white needles, mp 119°-121° C.

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