반응 #213945

반응 방정식

3-(4-methylphenyl)-6-isobutylaminotetrahydro-1,3,5-triazine-2,4-dione

acetic anhydride

→

3-(4-methylphenyl)-6-[(N-acetyl) isobutylamino]tetrahydro-1,3,5-triazine-2,4dione

수율 83.0%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux with slow distillation for 6 hours
3. 3
   온도cooled
4. 4
   기타evaporated
5. 5
   기타was recrystallised from ethanol (100 ml.)

실험 절차

A mixture of 3-(4-methylphenyl)-6-isobutylaminotetrahydro-1,3,5-triazine-2,4-dione (20 g.) and acetic anhydride (150 ml.) was heated under reflux with slow distillation for 6 hours, cooled and evaporated. The residual oil solidified in 20 hours and was recrystallised from ethanol (100 ml.) to give 3-(4-methylphenyl)-6-[(N-acetyl) isobutylamino]tetrahydro-1,3,5-triazine-2,4dione (19.4 g., 83%) m.p. 159°-160° C.

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