반응 #2139282

반응 방정식

t-butyl 2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate 1-oxide

→

2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylic acid 1-oxide

수율 93.6%

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   기타The solvent was then evaporated
2. 2
   workup.ADDITIONdiethyl ether was added
3. 3
   기타the solvent was evaporated again
4. 4
   workup.ADDITIONDiethyl ether was added again
5. 5
   여과the solid was filtered
6. 6
   기타dried under vacuum at room temperature

실험 절차

5.6 g of t-butyl 2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate 1-oxide, prepared by the procedure of Step C of Example II, were dissolved in 40 ml of trifluoroacetic acid and the solution was stirred for 15 minutes at room temperature. The solvent was then evaporated, diethyl ether was added and the solvent was evaporated again. Diethyl ether was added again and the solid was filtered and dried under vacuum at room temperature to obtain 4.72 g (93.6% yield) of 2-bromo-3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylic acid 1-oxide as a pale yellow solid.

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