반응 #213864

반응 방정식

sodium cyanide

3-(cyclohexylamino)propanesulfonic acid

cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl chloride

3-phenoxybenzaldehyde

→

α-cyano-3-phenoxybenzyl cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

용매

water

n-heptane

반응 조건

후처리

1. 1
   온도was warmed to 40°
2. 2
   온도maintaining a reaction temperature of about 40°
3. 3
   세척after which it was washed with an aqueous solution
4. 4
   workup.ADDITIONcontaining 20% sodium carbonate
5. 5
   기타The organic phase was separated from the mixture
6. 6
   기타the solvent removed by distillation under reduced pressure

실험 절차

A stirred mixture of sodium cyanide (18.0 g, 0.36 mole) and 3-(cyclohexylamino)propanesulfonic acid (1.34 g, 0.006 mole) in 300 ml of water was warmed to 40°. During a one hour period, maintaining a reaction temperature of about 40°, a solution of cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl chloride (71.7 g, 0.315 mole) and 3-phenoxybenzaldehyde (61.9 g, 0.3 mole) in 262.2 g of n-heptane was added. The mixture was then stirred at 40° for one additional hour, after which it was washed with an aqueous solution containing 20% sodium carbonate and then with water. The organic phase was separated from the mixture and the solvent removed by distillation under reduced pressure to give α-cyano-3-phenoxybenzyl cis-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate.

출처