반응 #2123302

반응 방정식

Water

3-Chloro-6-(1H-imidazol-1-yl)pyridazine

spiro[1-benzofuran-3,4′-piperidine]

triethylamine

→

product

수율 74.0%

1′-[6-(1H-imidazol-1-yl)pyridazin-3-yl]spiro[1-benzofuran-3,4′-piperidine]

수율 74.0%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   여과the resulting precipitate was collected by filtration
2. 2
   기타recrystallized from ethyl acetate-hexane

실험 절차

3-Chloro-6-(1H-imidazol-1-yl)pyridazine (180 mg), spiro[1-benzofuran-3,4′-piperidine] (200 mg) and triethylamine (0.42 mL) were dissolved in N,N-dimethylformamide (1 mL), and the solution was stirred at 160° C. under irradiation of microwave for 20 min. Water (10 mL) was added, and the resulting precipitate was collected by filtration, and recrystallized from ethyl acetate-hexane to give the object product (245 mg, 74%).

출처