반응 #2122537

반응 방정식

(S)-benzyl 2-oxooxetan-3-ylcarbamate

pyrazole

→

(S)-2-(benzyloxycarbonylamino)-3-(1H-pyrazol-1-yl)propanoic acid

수율 37.7%

용매

CH3CN

반응 조건

후처리

1. 1
   온도The mixture was cooled to rt overnight
2. 2
   여과the solid filtered

실험 절차

A suspension of (S)-benzyl 2-oxooxetan-3-ylcarbamate (0.67 g, 3.03 mmol), and pyrazole (0.22 g, 3.29 mmol) in CH3CN (12 mL) was heated at 50° C. for 24 h. The mixture was cooled to rt overnight and the solid filtered to afford (S)-2-(benzyloxycarbonylamino)-3-(1H-pyrazol-1-yl)propanoic acid (330.1 mg). The filtrate was concentrated in vacuo and then triturated with a small amount of CH3CN (ca. 4 mL) to afford a second crop (43.5 mg). Total yield 370.4 mg (44%).

출처