반응 #2122520

반응 방정식

Compound 24

N,N,2-trimethylbenzo[d]thiazole-6-sulfonamide

p-toluenesulfonic acid methyl ester

→

Compound 25

수율 84.0%

6-(N,N-dimethylsulfamoyl)-2,3-dimethylbenzo[d]thiazole-3-ium tosylate

수율 84.0%

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   기타the resulting mass was triturated with ethyl acetate (25 ml) until an off-white solid
3. 3
   기타separated
4. 4
   기타The solid was collected by centrifugation
5. 5
   세척washed with ethyl acetate
6. 6
   기타dried under vacuum

실험 절차

A mixture of Compound 24 (2.0 g, 7.8 mmol) and p-toluenesulfonic acid methyl ester (2.2 g, 11.7 mmol) was heated in a pressure tube at 130° C. for 2 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (25 ml) until an off-white solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 2.9 g (84%) of Compound 25 whose structure is given below:

출처