반응 #2122515

반응 방정식

Chlorosulfonic acid

2-methylbenzoxazole

→

Compound 8

수율 59.9%

2-methylbenzoxazole-6-sulfonyl chloride

수율 59.9%

용매

반응 조건

후처리

1. 1
   기타of 15 min
2. 2
   온도After cooling
3. 3
   workup.ADDITIONmix
4. 4
   기타The white solid that separated
5. 5
   여과was collected by filtration
6. 6
   세척washed with water until washings
7. 7
   기타dried

실험 절차

Chlorosulfonic acid (12.5 ml, 187.8 mmol) was cooled in an ice bath and 2-methylbenzoxazole (5.0 g, 37.5 mmol) was carefully added drop wise over a period of 15 min. The combined mixture was heated at 115-120° C. for 16 hours. After cooling, the mixture was added very slowly to ca. 100 ml ice/water mix. The white solid that separated was collected by filtration, washed with water until washings were neutral and dried to yield 5.2 g (59%) of Compound 8, whose structure is given below:

출처