반응 #2122514

반응 방정식

Compound 3

N-(2-methylbenzothiazole-6-sulfonyl)piperidine

p-toluenesulfonic acid methyl ester

→

Compound 4

수율 86.0%

N-(2,3-dimethylbenzothiazole-6-sulfonyl)piperidine tosylate

수율 86.0%

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   기타the resulting mass was triturated with acetone (25 ml) until a gray colored solid
3. 3
   기타separated
4. 4
   기타The solid was collected by centrifugation
5. 5
   세척washed with acetone
6. 6
   기타dried under vacuum

실험 절차

A mixture of Compound 3 (1.0 g, 3.4 mmol) and p-toluenesulfonic acid methyl ester (0.94 g, 5.1 mmol) was heated in a pressure tube at 130° C. for 1 hour. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with acetone (25 ml) until a gray colored solid separated. The solid was collected by centrifugation, washed with acetone and dried under vacuum to yield 1.4 g (86%) of Compound 4 whose structure is given below:

출처