반응 #2122490

반응 방정식

1-Methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid

1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid

thionyl chloride

→

1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carbonyl chloride

용매

toluene

반응 조건

후처리

1. 1
   기타The solvent was evaporated

실험 절차

700 mg 1-Methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid (from Step 5) was dissolved in 10 ml toluene, 1 drop N,N-dimethylformamide was added, followed by 400 mg thionyl chloride. The mixture was heated to 100° C. for 1 hour, at which time the evolution of gas has ceased. The solvent was evaporated, to yield crude 1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carbonyl chloride.

출처