반응 #2119

반응 방정식

diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate

ethyl iodide

potassium carbonate

→

Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

용매

DMF

반응 조건

후처리

1. 1
   여과The solid was filtered off
2. 2
   농축the filtrate was concentrated under reduced pressure
3. 3
   여과filtered again
4. 4
   기타crystallized from diisopropyl ether

실험 절차

7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

출처