반응 #2115

반응 방정식

7-ethoxymethyl-3-methylxanthine

diethyl 4-chlorobutane-phosphonate

potassium carbonate

→

Diethyl [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]phosphonate

용매

DMF

반응 조건

후처리

1. 1
   여과filtered
2. 2
   농축the filtrate was concentrated under reduced pressure
3. 3
   여과filtered again
4. 4
   기타crystallized from diisopropyl ether

실험 절차

44.8 g (0.2 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of DMF, treated with 55 g (0.24 mol) of diethyl 4-chlorobutane-phosphonate and 50 g (0.32 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate. filtered again and crystallized from diisopropyl ether.

출처