반응 #2112

반응 방정식

7-benzyl-3-methylxanthine

diethyl 4-chlorobutanephosphonate

potassium carbonate

→

Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate

용매

dimethylformamide

반응 조건

후처리

1. 1
   여과filtered
2. 2
   농축the filtrate was concentrated under reduced pressure
3. 3
   여과filtered again
4. 4
   기타crystallized from diisopropyl ether

실험 절차

20.4 g (0.08 mol) of 7-benzyl-3-methylxanthine were suspended in 200 ml of dimethylformamide (DMF), treated with 22 g (0.96 mol) of diethyl 4-chlorobutanephosphonate and 13.8 g (0.1 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

출처