반응 #2109

반응 방정식

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

용매

dichloromethane

반응 조건

후처리

1. 1
   온도under reflux for 16 hours
2. 2
   세척The solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   건조dried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

실험 절차

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

출처