반응 #2106

반응 방정식

diethyl 5-hydroxypentylphosphonate

4-toluenesulfonyl chloride

→

Diethyl 5-p-toluenesulfonyloxypentylphosphonate

용매

pyridine

반응 조건

후처리

1. 1
   workup.ADDITIONtreated
2. 2
   농축The reaction mixture was concentrated under reduced pressure
3. 3
   세척washed several times with 20% strength citric acid solution and water
4. 4
   건조dried over sodium sulfate
5. 5
   기타After evaporating the solvent
6. 6
   기타which was employed without further purification

실험 절차

30 g (0.134 mol) of diethyl 5-hydroxypentylphosphonate (see Example 21) were dissolved in 200 ml of pyridine, and the solution was cooled to 0° C. and treated with stirring with 26.1 g (0.134 mol) of 4-toluenesulfonyl chloride. The reaction mixture was concentrated under reduced pressure, taken up in ethyl acetate, washed several times with 20% strength citric acid solution and water and dried over sodium sulfate. After evaporating the solvent, a pale yellow oil remained, which was employed without further purification.

출처