반응 #2095

반응 방정식

7-(4-diethylphosphonobutyl)-3-methylxanthine

diethyl 4-chlorobutanephosphonate

potassium carbonate

→

Diethyl 4-{7-[4-(diethoxyphosphoryl)butyl]-3-methylxanthin-1-yl}butyl-phosphonate

용매

DMF

반응 조건

후처리

1. 1
   여과The product was then filtered
2. 2
   농축the filtrate was concentrated under reduced pressure
3. 3
   기타the oily residue which remained was chromatographed on a silica gel column (eluent: ethyl acetate/methanol 10:1)

실험 절차

8 g (0.022 mol) of 7-(4-diethylphosphonobutyl)-3-methylxanthine (according to Example 24) were suspended in 100 ml of DMF, treated with 6.13 g (0.027 mol) of diethyl 4-chlorobutanephosphonate and 3.7 g (0.028 mol) of activated potassium carbonate and heated at 70° C. for 4 hours. The product was then filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was chromatographed on a silica gel column (eluent: ethyl acetate/methanol 10:1).

출처