반응 #2090

반응 방정식

1-ethyl-3-methylxanthine

diethyl chlorobutanephosphonate

potassium carbonate

→

Diethyl [4-(1-ethyl-3-methylxanthin-7-yl)butyl]phosphonate

반응 조건

후처리

1. 1
   여과The solution was filtered
2. 2
   기타the solvent was evaporated
3. 3
   기타the residue which remained was chromatographed (eluent: ethyl acetate/methanol 10: 1)
4. 4
   기타crystallized from ethyl acetate/diisopropyl ether

실험 절차

9.7 g (0.05 mol) of 1-ethyl-3-methylxanthine were stirred at 70° C. for 6 hours with 12.7 g (0.06 mol) of diethyl chlorobutanephosphonate and 8.3 g of potassium carbonate. The solution was filtered, the solvent was evaporated, and the residue which remained was chromatographed (eluent: ethyl acetate/methanol 10: 1) and crystallized from ethyl acetate/diisopropyl ether.

출처