반응 #2088

반응 방정식

7-ethoxymethyl-3-methylxanthine

ethyl iodide

potassium carbonate

→

7-Ethoxymethyl-1-ethyl-3-methylxanthine

용매

DMF

반응 조건

후처리

1. 1
   여과The solution was filtered
2. 2
   기타the residue which remained was crystallized in diisopropyl ether
3. 3
   기타28.7 g (85% of theory) of the title substance were obtained
4. 4
   기타employed without purification in Example 4b)

실험 절차

30 g (0.134 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of absolute DMF with 25 g (0.161 mol) of ethyl iodide and 22.2 g (0.161 mol) of potassium carbonate and the mixture was stirred at 70° C. for 5 hours. The solution was filtered and the residue which remained was crystallized in diisopropyl ether. 28.7 g (85% of theory) of the title substance were obtained and employed without purification in Example 4b).

출처