반응 #2087

반응 방정식

diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate

ammonia

→

Diethyl [4-(3-methylxanthin-7-yl)butyl]phosphonate

용매

ethanol

반응 조건

후처리

1. 1
   여과The catalyst was filtered off
2. 2
   기타the solvent was evaporated under reduced pressure
3. 3
   기타the residue which remained was crystallized from diisopropyl ether

실험 절차

13 g (0.03 mol) of diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate were suspended in 150 ml of ethanol with 2 g of palladium on activated carbon (10%) and, after addition of 3 ml of concentrated ammonia solution, hydrogenated with shaking at 1.5 bar in the course of 48 hours. The catalyst was filtered off, the solvent was evaporated under reduced pressure and the residue which remained was crystallized from diisopropyl ether.

출처