반응 #2084

반응 방정식

benzyl bromide

7-ethoxymethyl-3-methylxanthine

potassium carbonate

→

1-Benzyl-7-ethoxymethyl-3-methylxanthine

용매

dimethylformamide

반응 조건

후처리

1. 1
   여과The reaction solution was filtered hot
2. 2
   농축the filtrate was concentrated under reduced pressure
3. 3
   기타the residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

실험 절차

205 g (1.2 mol) of benzyl bromide were added to a suspension of 224 g (1 mol) of 7-ethoxymethyl-3-methylxanthine and 165 g of potassium carbonate in 1000 ml of dimethylformamide and the mixture was then stirred overnight at 90° C. The reaction solution was filtered hot, the filtrate was concentrated under reduced pressure and the residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

출처