반응 #2082615

반응 방정식

H2SO4

Rebaudioside A

KOH

→

rebaudioside C

수율 99.0%

용매

methanol

반응 조건

후처리

1. 1
   기타to yield a homogeneous solution which
2. 2
   온도was refluxed for 1.5 hours
3. 3
   기타Reaction
4. 4
   온도After cooling to 0°
5. 5
   농축The resultant mixture was then concentrated to dryness
6. 6
   기타the residue recrystallized from water

실험 절차

Rebaudioside A (0.2 mmol, 183 mg) was transferred to a 15 ml flask. Four ml each of 10% KOH and methanol were added and the resultant mixture heated to yield a homogeneous solution which was refluxed for 1.5 hours. Reaction was then judged complete by TLC analysis. After cooling to 0°; the reaction mixture was acidified to pH 3 with 10% H2SO4. The resultant mixture was then concentrated to dryness and the residue recrystallized from water to give 150 mg (99%) of pure rebaudioside C.

출처