반응 #2080911

ord-b12e5b38d40e46d7a7ec4d615573ec30

반응 방정식

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
Cc1cn2cc(O)ccc2n1
2-methyl-6-hydroxyimidazo[1,2-α]pyridine
→
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1ccc2nc(C)cn2c1
desired product
수율 13.0%
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1ccc2nc(C)cn2c1
2-methylimidazo[1,2-α]pyridin-6-yl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside
수율 13.0%

반응물

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
Cc1cn2cc(O)ccc2n1
2-methyl-6-hydroxyimidazo[1,2-α]pyridine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타obtained
  2. 2
    기타according to preparation 5

실험 절차

By carrying out the process in a manner similar to example 7, starting from 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide and 2-methyl-6-hydroxyimidazo[1,2-α]pyridine obtained according to preparation 5, the desired product is obtained in the form of a white solid with a yield of 13%.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07652032B2uspto-grants-2010_01