반응 #2080909

ord-bfd60092583440168b784bc38457e839

반응 방정식

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
Cn1cnc2c(O)cccc21
4-hydroxy-1-methyl-1H-benzimidazole
→
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1cccc2c1ncn2C
desired product
수율 38.0%
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1cccc2c1ncn2C
1-methyl-1H-benzimidazol-4-yl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside
수율 38.0%

반응물

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
Cn1cnc2c(O)cccc21
4-hydroxy-1-methyl-1H-benzimidazole

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

By carrying out the process in a manner similar to example 7, starting from 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide and 4-hydroxy-1-methyl-1H-benzimidazole, the desired product is obtained in the form of a white solid with a yield of 38%. The product obtained is used directly in the deacetylation step.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07652032B2uspto-grants-2010_01