반응 #2080908

ord-0d6c63c5f3c347a5a200404d82ace990

반응 방정식

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
Cc1cn2ccc(O)cc2n1
2-methyl-7-hydroxyimidazo[1,2-α]-pyridine
→
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1ccn2cc(C)nc2c1
desired product
수율 38.0%
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)CS[C@H]1Oc1ccn2cc(C)nc2c1
2-methylimidazo[1,2-α]pyridin-7-yl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside
수율 38.0%

반응물

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
Cc1cn2ccc(O)cc2n1
2-methyl-7-hydroxyimidazo[1,2-α]-pyridine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타obtained
  2. 2
    기타according to preparation 3

실험 절차

By carrying out the process in a manner similar to example 7, starting from 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide and 2-methyl-7-hydroxyimidazo[1,2-α]-pyridine obtained according to preparation 3, the desired product is obtained in the form of a white solid with a yield of 38%. The product obtained is used directly in the deacetylation step.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07652032B2uspto-grants-2010_01