반응 #2080904

ord-d941fc493946463dad2a1e76ef15103a

반응 방정식

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
COc1c(C(C)=O)c(O)c(OC)c2occc12
5-acetyl-4,7-dimethoxy-6-hydroxybenzofuran
→
COc1c(C(C)=O)c(O[C@@H]2SC[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)c(OC)c2occc12
desired product
COc1c(C(C)=O)c(O[C@@H]2SC[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)c(OC)c2occc12
5-acetyl-4,7-dimethoxy-6-benzofuranyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside

반응물

CC(=O)O[C@H]1[C@H](OC(C)=O)CSC(Br)[C@@H]1OC(C)=O
2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide
COc1c(C(C)=O)c(O)c(OC)c2occc12
5-acetyl-4,7-dimethoxy-6-hydroxybenzofuran

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

By carrying out the process in a manner similar to example 7, starting from 2,3,4-tri-O-acetyl-5-thio-D-xylopyranosyl bromide and 5-acetyl-4,7-dimethoxy-6-hydroxybenzofuran, the desired product is obtained and is directly used in the following deprotection step without prior purification.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07652032B2uspto-grants-2010_01