반응 #2075741

반응 방정식

MeI

nitrophenol

B2

2-bromo-3-nitrophenol

cesium carbonate

→

2-bromo-3-nitroanisole

수율 94.0%

용매

DMF

반응 조건

후처리

1. 1
   기타The DMF was evaporated
2. 2
   세척washed with water (1×200 mL), brine (4×100 mL)
3. 3
   건조dried (MgSO4)
4. 4
   여과filtered
5. 5
   기타evaporated

실험 절차

The nitrophenol starting material B2 (3.1 g; 14.2 mmol) was dissolved in DMF (20 mL) and to the solution was added ground cesium carbonate (5.58 g; 17.1 mmol) followed by MeI (2.6 mL; 42.5 mmol). The mixture was stirred at room temperature overnight. The DMF was evaporated, the residue taken up in ether (1×200 mL), washed with water (1×200 mL), brine (4×100 mL), dried (MgSO4), filtered and evaporated to afford the crude 2-bromo-3-nitroanisole B3 (94%; 3.1 g) as an orange solid.

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