반응 #2075739

반응 방정식

2-methyl-3-nitro anisole

→

2-methyl-3-methoxyaniline

수율 98.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타at atmospheric pressure and room temperature
2. 2
   기타for 19 h
3. 3
   여과The reaction mixture was filtered through a Celite pad
4. 4
   세척rinsed
5. 5
   기타evaporated to dryness

실험 절차

To a solution of 2-methyl-3-nitro anisole A1 (5.1 g; 30.33 mmol; requires ˜30 min to dissolve) in absolute ethanol (85 mL) was added 10% Pd/C catalyst (500 mg). The solution was hydrogenated under a hydrogen filled balloon at atmospheric pressure and room temperature for 19 h. The reaction mixture was filtered through a Celite pad, rinsed and evaporated to dryness to obtain 2-methyl-3-methoxyaniline A2 as a deep mauve oil (4.1 g; 29.81 mmol; 98% yield).

출처