반응 #2075697

반응 방정식

2,2,2-trifluoro-N-(2-methoxy-[1,3]dioxolan-4-ylmethyl)acetamide

octadecanol

pyridinium para-toluenesulfonate

→

2,2,2-trifluoro-N-(2-octadecyloxy-[1,3]dioxolan-4-ylmethyl)acetamide

용매

cyclohexane

반응 조건

후처리

1. 1
   기타The crude reaction product
2. 2
   세척washed with a saturated sodium hydrogen carbonate solution
3. 3
   건조with a saturated sodium chloride solution, dried over magnesium
4. 4
   농축sulfate and then concentrated to dryness

실험 절차

3 g of 2,2,2-trifluoro-N-(2-methoxy-[1,3]dioxolan-4-ylmethyl)acetamide (Ortho 1, 13.09 mmol) were mixed with 3.54 g of octadecanol (13.09 mmol). The mixture was melted at 80° C. and left for 2 hours after the addition of 32 mg of pyridinium para-toluenesulfonate (0.13 mmol). The crude reaction product was then dissolved in cyclohexane, washed with a saturated sodium hydrogen carbonate solution and then with a saturated sodium chloride solution, dried over magnesium. sulfate and then concentrated to dryness. This crude product was used as it was for the next step.

출처