반응 #2075693

반응 방정식

3-aminopropanol

tert-butyl bromoacetate

→

tert-butyl(3-hydroxypropylamino)-acetate

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   workup.ADDITIONwere then added dropwise while the reaction mixture
2. 2
   온도was maintained at 0° C
3. 3
   workup.ADDITIONAt the end of the addition (2 hours later), the reaction mixture

실험 절차

196 ml of 3-aminopropanol (2.56 mol) were diluted in 250 ml of dichloromethane and the whole was cooled to 0° C. on an ice bath. 20 g of tert-butyl bromoacetate (102.5 mmol), solubilized in 200 ml of dichloromethane, were then added dropwise while the reaction mixture was maintained at 0° C. At the end of the addition (2 hours later), the reaction mixture was left at room temperature for 3 hours.

출처