반응 #2075690

반응 방정식

3-aminopropan-1,2-diol

ethyl trifluoroacetate

→

pure colorless oil

수율 95.0%

N-(2,3-dihydroxypropyl)-2,2,2-trifluoroacetamide

수율 95.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타provided with a magnetic bar
2. 2
   기타The crude reaction product
3. 3
   기타was then evaporated to dryness

실험 절차

15 g of 3-aminopropan-1,2-diol (164.6 mmol) were solubilized in 100 ml of tetrahydrofuran in a round-bottomed flask provided with a magnetic bar. The reaction mixture was then cooled to 0° C. on an ice bath and 21.5 ml of ethyl trifluoroacetate (181.1 mmol) were gradually added. The reaction mixture was stirred for 2 hours at room temperature. The crude reaction product was then evaporated to dryness. 29 g of a pure colorless oil were thus obtained (yield: 95%), that product was used without further purification.

출처