반응 #2069962

반응 방정식

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

수율 80.1%

4-Bromo-1-isoquinolinol

수율 80.1%

용매

tetrahydrofuran

acetic acid

반응 조건

후처리

1. 1
   기타the resulting reaction mixture
2. 2
   여과was filtered
3. 3
   여과through filter paper
4. 4
   세척The organic layer was washed with saturated brine
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The residue was recrystallized from ethyl acetate and hexane

실험 절차

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

출처