반응 #2069952

반응 방정식

water

potassium carbonate

t-butyl bromide

4-pentynoic acid

→

title compound

t-Butyl 4-pentynoate

용매

N,N-dimethylacetamide

반응 조건

후처리

1. 1
   추출the reaction mixture was extracted with ethyl acetate
2. 2
   세척washed with water
3. 3
   건조dried over anhydrous magnesium chloride
4. 4
   여과filtered through silica gel
5. 5
   농축The filtrate was concentrated under reduced pressure

실험 절차

Benzyltriethylammonium chloride (5.92 g), potassium carbonate (93.4 g), and t-butyl bromide (143 ml) were added to a solution of 4-pentynoic acid (2550 mg) in N,N-dimethylacetamide (230 ml), and this reaction mixture was stirred at 55° C. for 24 hours. After water was added, the reaction mixture was extracted with ethyl acetate, washed with water, dried over anhydrous magnesium chloride, and then filtered through silica gel. The filtrate was concentrated under reduced pressure to give the title compound (2.10 g). This compound was used in the following reaction without further purification.

출처