반응 #2069929

반응 방정식

4-cyano-4′-hydroxybiphenyl

allyl bromide

potassium carbonate

2-butanone

→

4-allyloxy-4′-cyanobiphenyl

수율 91.3%

용매

Water

반응 조건

후처리

1. 1
   기타A solution prepared
2. 2
   온도was refluxed for 7 hours
3. 3
   세척the organic layer was washed with water
4. 4
   건조dried with anhydrous magnesium sulfate
5. 5
   기타The solvent was evaporated away
6. 6
   기타the resulting residue was purified through silica gel column chromatography
7. 7
   기타further recrystallized from ethanol

실험 절차

A solution prepared by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of allyl bromide and 25 g of potassium carbonate to 250 ml of 2-butanone was refluxed for 7 hours. Water was added to the reaction solution for liquid-liquid separation, and the organic layer was washed with water and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography using toluene as an eluent solvent and then further recrystallized from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

출처