반응 #2069926

반응 방정식

N-Acetyl-N,N-di(4-isopropylphenyl)amine

→

N,N-Di-(4-isopropylphenyl)amine

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONThe ethanolic solution is poured into dist
2. 2
   여과water, and the brownish precipitate is filtered off with suction
3. 3
   workup.DISSOLUTIONdissolved in dichloromethane
4. 4
   건조dried with sodium sulphate
5. 5
   농축The solution is concentrated
6. 6
   기타chromatographed through a short silica gel column with 50% dichloromethane in hexane
7. 7
   농축The product fractions are concentrated to dryness
8. 8
   기타the product is dried under reduced pressure

실험 절차

N-Acetyl-N,N-di(4-isopropylphenyl)amine (5.4 g, 18.4 mmol) are heated to reflux in 100 ml of 20% aqueous ethanol. The reaction is monitored by thin-layer chromatography. After 30 h, no reactant is any longer detectable in the TLC. The ethanolic solution is poured into dist. water, and the brownish precipitate is filtered off with suction, dissolved in dichloromethane and dried with sodium sulphate. The solution is concentrated and chromatographed through a short silica gel column with 50% dichloromethane in hexane. The product fractions are concentrated to dryness and the product is dried under reduced pressure.

출처