반응 #2066035

반응 방정식

ethyl hydrazinecarboxylate

3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

p-toluenesulfonic acid

→

3-(4-Chloro-3-ethoxycarbonylhydrazonomethylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

용매

toluene

반응 조건

후처리

1. 1
   세척the solution was washed once with water
2. 2
   건조the organic phase was dried over sodium sulfate
3. 3
   기타evaporated down
4. 4
   기타The precipitate was isolated
5. 5
   세척washed with petroleum ether
6. 6
   기타dried

실험 절차

1.0 g of ethyl hydrazinecarboxylate was added to a solution of 3.3 g of 3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine and 0.1 g of p-toluenesulfonic acid in 150 ml of toluene. After 2 hours, the solution was washed once with water, the organic phase was dried over sodium sulfate and evaporated down and the residue was stirred with petroleum ether. The precipitate was isolated, washed with petroleum ether and dried.

출처